What is AP 2?
The AP2 adaptor complex is a multimeric protein that works on the cell membrane to internalize cargo in clathrin-mediated endocytosis. It is a stable complex of four adaptins which give rise to a structure that has a core domain and two appendage domains attached to the core domain by polypeptide linkers.
What is AP gene?
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections.
What is the p52 gene?
p100/p52 cDNA / Gene Function This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function.
Where is AP2 found?
AP2 is known to exist in a ‘locked’, inactive state in the cytoplasm and to become ‘open’ and permissive to cargo and clathrin binding at membranes containing phosphatidylinositol-3,4-bisphosphate (PtdIns(4,5)P2).
What increases the activity of AP-1?
Furthermore, environmental or dietary carcinogens have been shown to induce increased AP1 activity (Abate and Curran, 1990; Verma et al., 1990). Many human cancers exhibit overexpression of Jun family members (Neyns et al., 1996; Langer et al., 2006; Kharman-Biz et al., 2013).
What does a genetic map show?
[Genetic map] is a map that shows the relative location of two genetic traits. And the way to do this is to use the offspring of an organism and track how many times two given genetic traits are inherited together; for instance, hair color and eye color.
What is p52 used for?
The trypanosomal MAP (p52) has been used in an antigenic preparation with the enzymes aldolase and GAPDH as a vaccine in mice and rats. The p52 was isolated from T. b. brucei, and when the animals were immunized three times over a period of 3 weeks 100% protection was achieved (Rasooly and Balaban, 2004).
What is the function of p53?
A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death. Mutations (changes) in the p53 gene may cause cancer cells to grow and spread in the body.
What do Adaptins do?
Adaptins are subunits of adaptor protein (AP) complexes involved in the formation of intracellular transport vesicles and in the selection of cargo for incorporation into the vesicles.
What is transcription factor AP-2 alpha?
Transcription factor AP-2 alpha is a 52-kD sequence-specific DNA-binding protein that enhances transcription of specific genes by binding to a GC-rich DNA sequence first identified in the cis-regulatory region of SV40 virus DNA and in cis-regulatory regions of a variety of cellular genes.
What is ap-2α?
Transcription factor AP-2α is one of a group of related proteins called AP-2 transcription factors. These proteins regulate genes that help control cell division and the self-destruction (apoptosis) of cells that are no longer needed.
What chromosome is AP-2 found on?
“Localization of the gene for the DNA-binding protein AP-2 to human chromosome 6p22.3-pter”. Genomics. 10 (4): 1100–2. doi: 10.1016/0888-7543 (91)90209-W. PMID 1916817. Williams T, Tjian R (Mar 1991). “Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins”. Science. 251 (4997): 1067–71.
Where is AP-2 alpha expressed in the brain?
Transcription factor AP-2 alpha is expressed in ectoderm and in neural-crest cells migrating from the cranial folds during closure of the neural tube in the mouse. Cranial neural crest cell provides patterning information for craniofacial morphogenesis and generate most of the skull bones and the cranial ganglia.