What does RUVBL2 stand for?
RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins. This gene encodes the second human homologue of the bacterial RuvB gene.
Does EHF-mediated RUVBL1 expression protect colon tumour cells from p53-mediated apoptosis?
These results indicate that EHF-mediated RUVBL1 expression allows colon tumour cells to avoid p53-mediated apoptosis. S100A9 and NMP238 expression is associated with concurrent chemoradiotherapy sensitivity in cervical carcinoma. RUVBL1 and RUVBL2 control the abundance of Phosphatidylinositol 3-kinase…
What is the role of RUVBL1 in squamous cell carcinoma?
RUVBL1 is an amplified epigenetic factor promoting proliferation and inhibiting differentiation program in head and neck squamous cancers. Deregulated levels of RUVBL1 induce transcription-dependent replication stress.
Does RUVBL1 cause hepatic insulin resistance in hepatocellular carcinoma?
Liver haploinsufficiency of RuvBL1 causes hepatic insulin resistance and enhances hepatocellular carcinoma progression. NOPCHAP1 is a PAQosome cofactor that helps loading NOP58 on RUVBL1/2 during box C/D snoRNP biogenesis. Genetic variant of RUVBL1 is associated with epithelial ovarian cancer.
Is RUVBL2 RuvB like AAA ATPase 2 (human)?
RUVBL2 RuvB like AAA ATPase 2 [ (human)] Summary. This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities.
Is RUVBL2 essential for the oncogenic function of c-Myb in AML?
These data demonstrate that RUVBL2 is essential for the oncogenic function of c-MYB in AML by governing inhibition of myeloid differentiation. They also indicate that targeting the control of c-MYB function by RUVBL2 is a promising approach to developing future anti-AML therapies.
Can form a dodecamer with RUVBL1 in equimolar ratio?
Can form a dodecamer with RUVBL1 made of two stacked hexameric rings; however, even though RUVBL1 and RUVBL2 are present in equimolar ratio, the oligomeric status of each hexamer is not known. Oligomerization may regulate binding to nucleic acids and conversely, binding to nucleic acids may affect the dodecameric assembly.