Where did J2 originate?
Origins. Haplogroup J2 is thought to have appeared somewhere in the Middle East towards the end of the last glaciation, between 15,000 and 22,000 years ago. The oldest known J2a samples at present were identified in remains from the Hotu Cave in northern Iran, dating from 9100-8600 BCE (Lazaridis et al.
What is J1 in DNA?
In genetic genealogy and human genetics, Y DNA haplogroup J-M267, also commonly known as haplogroup J1, is a subclade (branch) of Y-DNA haplogroup J-P209 (commonly known as haplogroup J) along with its sibling clade Y DNA haplogroup J-M172 (commonly known as haplogroup J2).
What is haplo?
Haplo, is short for haploid, and means single. This refers to the fact that we have a single copy (or version) of the Y-DNA and a single version of the mtDNA in our bodies.
Where did J1 originate?
The major branch—J1a1a1-P58—evolved during the early Holocene ~ 9500 years ago somewhere in the Arabian Peninsula, the Levant, and southern Mesopotamia.
Where does J1 come from?
The oldest identified J1 sample to date comes from Satsurblia cave (c. 13200 BCE) in Georgia (Jones et al. (2015)), placing the origins of haplogroup J1 in all likelihood in the region around the Caucasus, Zagros, Taurus and eastern Anatolia during the Upper Paleolithic.
What is Allo BMT?
Listen to pronunciation. (A-loh-jeh-NAY-ik bone MAYR-oh TRANZ-plant) A procedure in which a patient receives healthy stem cells (blood-forming cells) to replace their own stem cells that have been destroyed by treatment with radiation or high doses of chemotherapy.
What is haplo match?
A haploidentical transplant (haplo) is a half matched stem cell transplant from a family member. Haplo donors can be parents, children, siblings, and sometimes cousins of the patient. A biologic parent or a biologic child is always a half match to the patient, based on genetics.
What is a 10 10 HLA match?
Matching for the HLA-A, -B,- C,- DRB1 and -DQB1 loci is referred to as a 10/10 match, when HLA-DPB1 is included it becomes a 12/12 match. Matching for HLA-A, -B, -C, and -DRB1 loci is an 8/8 match. There is still no international standard for reporting DRB3/4/5 as well as DQA1 and DPA1 mismatches.
Why is a matched sibling the best possible donor?
HLA-matched sibling donors (MSDs) remain the best donor source because of rapid hematopoietic and immunologic reconstitution and lower incidences of infections and acute graft-versus-host disease (GVHD), but only 25–30% of patients can undergo HLA-matched sibling donor transplantation (MSDT).
What is a 12 12 HLA match?
Matching for 12 HLA Alleles Is Associated with a Significantly Superior Survival Due to a Lower Mortality in Recipients of Unrelated Donor Haematopoietic Cell Transplants for Early but Not Late Stage Leukaemia.
What is Haplogroup J2 in humans?
In human genetics, Haplogroup J2 (M172) is a Y-chromosome haplogroup which is a subdivision of haplogroup J. Haplogroup J2 is widely believed to be associated with the spread of agriculture from the northern Fertile Crescent, the Levant, and Anatolia [2], [3].
What is Haplogroup J-M172?
Haplogroup J-M172 is common in modern populations in Western Asia, Central Asia, South Asia, Europe, Northwestern Iran and North Africa. It is thought that J-M172 may have originated between the Mesopotamia, Levant and/or Iran. It is further divided into two complementary clades, J-M410 and J-M12 (M12, M102, M221, M314).
Where are the descendants of haplogroup J today?
Today, descendants of Haplogroup J can be found all over the world, defined by the Y-SNP mutation called J-M304. When this mutation was new, it first laid down firm footing in Western Asia and spread from there, giving rise to high concentrations of descendants in the Arabian Peninsula.
What is Y-chromosome haplogroup J?
The Y-chromosome Haplogroup Tree is our first stop in dissecting Haplogroup J. It’s the great tree of the family of man. In terms of age, the first men with the Haplogroup J mutation lived well before anybody in haplogroups to its right in the tree.