What is the incidence of Chagas disease?
In the Americas, Chagas disease show an annual incidence of 30,000 new cases average, 12,000 deaths per year, and 8,600 newborns become infected during gestation. It is estimated that around 70 million people in the Americas live in areas of exposure and are at risk of contracting this disease.
When was Chagas disease first discovered?
Chagas disease is named after the Brazilian physician Carlos Chagas, who discovered the disease in 1909. It is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread).
Where was Chagas disease first discovered?
Carlos Ribeiro Justiniano das Chagas in his laboratory at the Federal Serotherapy Institute in Manguinhos, Rio de Janeiro. The Brazilian hygienist, scientist and bacteriologist identified the protozoan parasite T.
What is the mortality rate of Chagas disease?
Chagas disease was identified in 122,291 deaths (0.54%), 94.788 (77.5%) as an underlying cause and 27,503 (22.5%) as an associated cause. Average annual age-adjusted mortality rate was 3.22 deaths/100,000 inhabitants (95% confidence interval [CI]: 3.14-3.30).
What is Chagas disease caused by?
Chagas disease is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by insect vectors and is found only in the Americas (mainly, in rural areas of Latin America where poverty is widespread). Chagas disease (T. cruzi infection) is also referred to as American trypanosomiasis.
Who is most at risk for Chagas disease?
The following factors may increase your risk of getting Chagas disease:
- Living in poor rural areas of Central America, South America and Mexico.
- Living in a residence that contains triatomine bugs.
- Receiving a blood transfusion or organ transplant from a person who carries the infection.
What is the life cycle of Chagas disease?
cruzi has a complex life cycle involving both vertebrate and invertebrate hosts in three well-defined developmental stages: (1) amastigotes, which are the proliferative forms found inside the vertebrate host cells; (2) epimastigotes, which are the proliferative forms found in the intestine of the invertebrate host; and …
How does Chagas disease cause death?
In persons with chronic chagasic heart disease, mortality is primarily due to the rhythm disturbances and congestive heart failure that result from the chronic inflammatory cardiomyopathy driven by the persistent presence of parasites in heart tissue.
Can Chagas cause death?
Chagas disease causes approximately 10,000 deaths per year globally. Up to 30% of infected people develop symptoms. Chagas disease can cause: Stroke.