What is the function of vimentin?
Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously expressed in normal mesenchymal cells and is known to maintain cellular integrity and provide resistance against stress.
Is vimentin an antigen?
Citrullinated vimentin is known to be an important antigen in RA [35] and is present in synovial fluid [21], but its presence in IC has not been reported.
What does a positive vimentin mean?
Mesenchymal and endothelial cells usually stain vimentin positive and thus act as a measure of internal quality control in immunoreactivity. Absence of immunostaining in these areas often indicates that there is significant damage to tissue antigens and loss of structural architecture.
What is vimentin gene?
VIM Gene – Vimentin This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions.
What tumors are vimentin positive?
The aberrant overexpression of vimentin has been linked to a more aggressive status in various tumors including melanoma (8), breast cancer (9, 10), cervical carcinoma (11), renal cell carcinoma (12), and prostate carcinoma (13).
Is vimentin a nucleus?
Very early, ball-like structures, or “knots,” are seen and often vimentin filaments emerge in the shape of rings around the nucleus. Although intermediate filaments are not known to be associated to motor proteins to form contractile systems, these rings can nonetheless strongly deform the cell nucleus.
Where is vimentin expressed?
mesenchymal cells
Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all animal cells as well as bacteria.
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