What is the drug flumazenil used for?
Flumazenil injection is indicated for a complete or partial reversal of the sedative effects of benzodiazepines in conscious sedation and general anesthesia in adult and pediatric populations.
What drugs can flumazenil reverse?
Romazicon (Flumazenil) is a benzodiazepine antogonist used to reverse Versed (Midazolam) and Valium (Diazepam). It also has a rapid onset of action, producing a reversal in less than one minute. A dose of 0.2 – 1 mg is given slowly intravenously with a dose not exceeding 0.2 mg/min.
What type of drug is flumazenil?
Flumazenil (trademarked as Romazicon and Anexate) is a benzodiazepine antagonist, a type of drug that counteracts the effects of benzodiazepines. It does this by helping block the binding of benzodiazepine drugs to the GABA receptor. It can be given as an intravenous injection or a continuous intravenous infusion.
Why is flumazenil not recommended?
Flumazenil lowers the seizure threshold and may lead to life-threatening seizures. It should be avoided or used with extreme caution in settings of benzodiazepine dependence, seizure disorder, cyclic antidepressant overdose, and elevated intracranial pressure.
Is flumazenil a pill?
Flumazenil is given as an infusion into a vein. A healthcare provider will give you this injection. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when flumazenil is injected.
Is flumazenil a GABA antagonist?
Flumazenil is best known as a competitive antagonist at the benzodiazepine-binding site on the GABAA receptor, and has long-standing clinical use as an emergency treatment for benzodiazepine overdose.
What is another name for flumazenil?
Flumazenil is sold under a wide variety of brand names worldwide like Anexate, Lanexat, Mazicon, Romazicon.
What is the brand name of flumazenil?
BRAND NAME(S): Romazicon. WARNING: Flumazenil can cause seizures, especially in patients who have been on benzodiazepines (e.g., diazepam) for a long time or if patient has taken too much of a benzodiazepine (overdose). USES: This medication reverses the sedative effects of certain medications.
Is flumazenil a controlled drug?
Drug Abuse And Dependence Although flumazenil has a benzodiazepine-like structure it does not act as a benzodiazepine agonist in man and is not a controlled substance.
Is flumazenil a generic name?
GENERIC NAME: FLUMAZENIL – INJECTION (flew-MAY-zee-nill)
What is the other name for flumazenil?
How do you give flumazenil?
To minimize the likelihood of pain or inflammation at the injection site, flumazenil should be administered through a freely flowing intravenous infusion into a large vein. Local irritation may occur following extravasation into perivascular tissues.
What is the activity of flumazenil?
This activity outlines the indications, mechanism of action, dosing, significant adverse effects, contraindications, monitoring, and toxicity of flumazenil so that providers can direct patient therapy to optimal outcomes in benzodiazepine reversal. Flumazenil is a benzodiazepine antagonist.
What are the treatment options for flumazenil toxicity?
There is no precise antidote for flumazenil toxicity In mild to severe toxicity, symptomatic and supportive treatment should be a consideration. An overdose of flumazenil in a patient who is not a chronic benzodiazepine user would not be expected. Chronic benzodiazepines users experience withdrawal with abrupt discontinuation of the drug. [20][21]
Is flumazenil a benzodiazepine antagonist?
ReviewFlumazenil: a benzodiazepine antagonist. [DICP. 1990] ReviewFlumazenil: a benzodiazepine antagonist. Karavokiros KA, Tsipis GB. DICP. 1990 Oct; 24(10):976-81. ReviewFlumazenil in benzodiazepine antagonism. Actions and clinical use in intoxications and anaesthesiology. [Med Toxicol Adverse Drug Exp. …]
What are the possible complications of flumazenil (fluconazole)?
Contact a medical toxicologist or local poison center for any patient with suspected severe adverse effects after receiving flumazenil, such as seizures, dysrhythmias, and hypotension. It is important to note that seizures after flumazenil administration are significantly associated with exposure to a pro-convulsant drug. [22]