What is the difference between paclitaxel and docetaxel?
In conclusion, docetaxel (100 mg/m2 every 3 weeks) demonstrated superior efficacy compared with paclitaxel (175 mg/m2 every 3 weeks), providing significant clinical benefit in terms of survival and time to disease progression, with a numerically higher response rate and manageable toxicities.
What type of drug is docetaxel?
Drug type: Docetaxel is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as a “plant alkaloid,” a “taxane” and an “antimicrotubule agent.” (For more detail, see “How this drug works” section below).
Is docetaxel platinum based?
A new non-platinum sequential triplet combination chemotherapy regimen, comprising gemcitabine (1000 mg/m(2)) and vinorelbine (25 mg/m(2)), followed by docetaxel (60 mg/m(2)), was compared in terms of efficacy, toxicity and cost with platinum-based chemotherapy regimens (comprising cisplatin plus one or more other anti …
How is docetaxel supplied?
The recommended dose of Docetaxel Injection is 75 mg/m2 administered intravenously over 1 hour immediately followed by cisplatin 75 mg/m2 over 30-60 minutes every 3 weeks [see Dosage and Administration (2.7)].
Which is more effective docetaxel or paclitaxel?
Docetaxel has demonstrated greater efficacy versus solvent-based paclitaxel in at least one trial, but both solvent-based paclitaxel and docetaxel are associated with undesirable dose-limiting toxicities, including neutropenia, sensory neuropathy, and hypersensitivity reactions.
What is docetaxel target?
Docetaxel exhibits cytotoxic activity on breast, colorectal, lung, ovarian, gastric, renal and prostate cancer cells. Docetaxel does not block disassembly of interphase microtubules and so does not prevent entry into the mitotic cycle, but does block mitosis by inhibiting mitotic spindle assembly.