What is Robertsonian translocation karyotype?
In Robertsonian translocation, the pericentric regions of two acrocentric chromosomes fuse to form a single centromere or two. The resulting balanced karyotype has only 45 chromosomes including the translocated one, which is the result of a fusion of the long arms of two acrocentric chromosomes (5).
What is Robertsonian translocation Down syndrome?
The Robertsonian translocation is unbalanced and the baby has three copies of the long arm of chromosome 21 instead of two. This causes a type of Down’s syndrome called translocation Down’s syndrome. The effects on the baby are exactly the same as when Down’s syndrome is caused by having an extra entire chromosome 21.
What happens if you have balanced translocation?
Balanced translocation carriers are burdened with fertility issues due to improper chromosome segregation in gametes, resulting in either implantation failure, miscarriage or birth of a child with chromosomal disorders.
Is Robertsonian translocation inherited?
Causes. Robertsonian translocation is a genetic disorder. People inherit it from their parents with the mother or father passing it to a child in their genes.
Can Robertsonian translocation have baby?
A woman with a Robertsonian translocation has a high risk of miscarriage or having a child with a disability. But, the miscarriage risk is pretty low in Robertsonian translocation carriers. Some men with a Robertsonian translocation have lowered sperm count — or a lessened ability to produce sperm.
Is chromosomal translocation hereditary?
A translocation is either inherited from a parent or happens around the time of conception. A translocation cannot be corrected – it is present for life. A translocation is not something that can be “caught” from other people. Therefore a translocation carrier can still be a blood donor, for example.