What is early virologic response?
Early virologic response (EVR) is defined as a ⩾2‐log10 decrease in the HCV RNA level or as an undetectable HCV RNA level by week 12 of therapy [1, 5] and is regarded as a robust indicator of treatment outcome, with a negative predictive value of 97%–100% for SVR [4, 6].
What is the most important factor affecting the virologic response to HCV therapy?
The single most important viral factor that influences the response to antiviral treatment is HCV genotype, and the most important host factors are IL28B genotype and liver fibrosis[12-14].
What is the definition of a sustained virologic response 12 SVR12?
A sustained virologic response is defined as an undetectable HCV RNA level 12 weeks after stopping antivirals; this is referred to as the SVR12, and the SVR12 has a high correlation with SVR24. An SVR is durable and indicates HCV cure.
What are red flag signs of hep C?
- Bleeding easily.
- Bruising easily.
- Poor appetite.
- Yellow discoloration of the skin and eyes (jaundice)
- Dark-colored urine.
- Itchy skin.
- Fluid buildup in your abdomen (ascites)
Which type of HCV has the worst response to interferon treatment?
Patients with viral loads greater than 2,000,000 copies per milliliter or 800.000 IU/mL have the worst responses. Within protein NS5A, a region of 40 amino acids called the interferon sensitivity-determining region (ISDR) is associated with responsiveness to treatment with interferon alfa.
Which factor is associated with a more favorable outcome in a patient with HCV infection?
Which factor is associated with a more favorable outcome in a patient with HCV infection? The onset of chronic HCV infection early in life frequently leads to less serious consequences and more favorable outcomes.
What is virologic cure?
Sustained virologic response means that the hepatitis C virus is not detected in the blood 12 weeks or more after completing treatment. Is SVR the same as “cure”? About 99% of people are considered cured of their infection when the virus is not detected 12 weeks or more after completing treatment.
Can Hep C come back after Harvoni treatment?
It’s possible, but rare, for hepatitis C infection to reappear after apparently successful treatment. Relapses usually occur in the first few months after blood testing to confirm that the virus is no longer detectable.