What is dissolution medium?
Abstract. Choice of a dissolution medium is an important and critical variant for drug dissolution testing. The reported choices range from a simple solvent (water) to complex solutions, often drug and/or product dependent.
What is the mode of action for glibenclamide?
The mechanism of action of the drug consists in the inhibition of the ATP-sensitive K+ channels, which leads to depolarization of the cells and insulin secretion. Based on the same mechanism are also the extrapancreatic action of the drug at the liver, skeletal muscle, heart muscle and smooth muscle sites.
What is glibenclamide tablet use for?
Glibenclamide (GBC) is an oral hypoglycemic drug that stimulates the pancreatic beta cells to secrete insulin and is often used to treat diabetes, including diabetes during pregnancy.
What is the strength of glibenclamide?
Dosage and duration The usual dose is 5 mg 2 times daily (max. 15 mg daily).
How do you calculate dissolution?
To convert this equation in x = Y-c / m (Y = Abs.) DF: dilution factor is indicate number time to dilute the given solution (10, 100 and 1000). Conc µg/ml: DF * Conc µg/ml to get Conc µg/ml. Conc mg/ml: Conc µg/ml / 1000 to get Conc mg/ml.
What is the side effect of glibenclamide?
What side effects can Glibenclamide cause? This medication may cause low blood sugar (hypoglycemia). Symptoms of low blood sugar are weakness, dizziness, hunger, sweating, trembling, blurred vision, walking unsteadily or fast heartbeat.
How is glibenclamide excreted?
Human Pharmacokinetics It is metabolized almost completely in the liver to weakly active metabolites and excreted in equal proportions in both the bile and via the kidneys Goldfine and Maratos-Flier (2001).
What is glibenclamide 5mg?
The name of your medicine is Glibenclamide 5 mg Tablets. Glibenclamide is a medicine taken by mouth to help lower blood sugar. It belongs to a group of medicines called sulfonylureas. Glibenclamide works by increasing the amount of insulin released from your pancreas.
Is glimepiride same as glibenclamide?
Glimepiride is safer than glibenclamide, especially in serious hypoglycemia. Glimepiride was similar to glibenclamide in protecting against ischemic stroke. Neurological function and blood-brain barrier were protected. Infarct volume, cerebral edema and inflammatory reaction were lightened.
What is Q value in dissolution?
Answer: Q represents the targeted amount of active substance, expressed as a percentage of the label claim, which should be dissolved within a certain time. The ‘Q value’ should be seen as a “reference value” to which the dissolution results are compared.
How to carry out the dissolution test for glibenclamide?
Optimal conditions to carry out the dissolution test are 500 mL of phosphate buffer at pH 8.0, paddles at 75 rpm stirring speed, time test set to 60 min and using equipment with six vessels. The derivative UV spectrophotometric method for determination of glibenclamide released was developed, validated and compared with the HPLC method.
What is the solubility and permeability of glibenclamide?
Glibenclamide is antidiabetic which based on the Biopharmaceutical Classification System (BCS), has low solubility and high permeability which causes low bioavailability. Cocrystallization is the process to enhance the physical properties of drugs, especially the solubility.
What is the dissolution rate of co-crystallized glibenclamide?
The dissolution rate had also increased from 46.838% of pure glibenclamide to 77.655% of glibenclamide co-crystal in 60 min. There was no chemical reaction observed during the co-crystallization process based on the IR spectrum.
What is the concentration of glibenclamide released by UV spectrophotometry?
The derivative UV spectrophotometric method for determination of glibenclamide released was developed, validated and compared with the HPLC method. The UVDS method presents linearity (r (2) = 0.9999) in the concentration range of 5-14 mu g/mL.