What does IDMS traceable creatinine mean?
IDMS traceability means that the creatinine method used (e.g., enzymatic, Jaffe method) has calibration traceable to an IDMS reference measurement procedure.
What is eGFR IDMS?
An estimated glomerular filtration rate (eGFR) of greater than 60 milliliters per minute per 1.73 meters squared is a normal result for a 68 year old man. The IDMS is an acronym that indicates the method of measuring the blood creatinine and stands for Isotope Dilution Mass Spectroscopy calibrated method.
How is inulin clearance calculated?
Plasma clearance of inulin can be calculated by dividing the dose by the area under the plasma concentration/time curve.
What is a normal glomerular filtration rate?
A GFR of 60 or higher is in the normal range. A GFR below 60 may mean kidney disease. A GFR of 15 or lower may mean kidney failure.
What is a normal GFR for African American?
An eGFR score of 60 or higher indicates normal functioning. An eGFR score of under 60 may indicate kidney disease. An eGFR score of under 15 may indicate kidney failure.
What is glomerular filtration rate?
Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood.
What is the IDMS-traceable MDRD Study equation?
The following is the IDMS-traceable MDRD Study equation (for creatinine methods calibrated to an IDMS reference method) GFR (mL/min/1.73 m 2) = 175 × (S cr) -1.154 × (Age) -0.203 × (0.742 if female) × (1.212 if African American)
Why should I use an IDMS traceable equation when estimating GFR?
Because creatinine results that are calibrated to IDMS may differ by 5 to 30% compared to uncalibrated results, 1 use of a non-IDMS traceable equation with IDMS calibrated results will yield an inaccurate eGFR. Therefore, all laboratories should use an IDMS traceable equation when estimating and reporting GFR.
What percentage of labs use IDMS calibration with serum creatinine?
In 2019, 76% of laboratories surveyed by the College of American Pathologists (CAP) were using an IDMS-traceable calibration with serum creatinine, a slight decrease from 2017 (78%), but a significant increase from 2007 (26%).
Is the IDMS-traceable modification of diet in Renal Disease Study equation accurate?
1.Following implementation of revised calibration for serum creatinine methods, use of the IDMS-traceable Modification of Diet in Renal Disease (MDRD) Study equation will give a more accurate value for eGFR in adults. [Dave: wondering why? See “Serum creatinine assay errors” below.