What class of drug is mexiletine?
Descriptions. Mexiletine belongs to the group of medicines known as antiarrhythmics. It is used to correct irregular heartbeats to a normal rhythm.
What is the generic name for mexiletine?
Oral Antiarrhythmic MEXITIL® (mexiletine hydrochloride, USP) is an orally active antiarrhythmic agent available as 150 mg, 200 mg and 250 mg capsules.
Is mexiletine FDA approved?
Approval Date: 4…
How long does mexiletine take to work?
Mexiletine typically starts to work 2 or 3 hours after you take a dose. If you are in the hospital, you might get you a higher “loading dose” so that the medication kicks in faster.
What happens if you take too much mexiletine?
Overdose symptoms may include nausea, drowsiness, confusion, feeling lightheaded, seizures, loss of consciousness, and a worsening irregular heartbeat. Other drugs may interact with mexiletine, including prescription and over-the-counter medicines, vitamins, and herbal products.
What are side effects of mexiletine?
Mexiletine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea.
- vomiting.
- heartburn.
- changes in appetite.
- lightheadedness or dizziness.
- shaking of a part of your body that you cannot control.
- loss of coordination.
- numbness or tingling sensation.
How long does it take for mexiletine to work?
What blocks amiodarone?
Amiodarone is a class III antiarrhythmic that blocks potassium channels. In acute therapy, most of its effects are due to its action as a sodium channel blocker, thereby reducing automaticity and conduction velocity in the ventricles.
What is mexiletine USP?
Mexiletine Description. Mexiletine hydrochloride, USP is an orally active antiarrhythmic agent. It is a white to off-white crystalline powder with slightly bitter taste, freely soluble in water and in alcohol. Mexiletine hydrochloride, USP has a pKa of 9.2.
What is the composition of mexiletine hydrochloride?
C 11 H 17 NO • HCl M.W. 215.72 Each capsule for oral administration, contains 150 mg, 200 mg and 250 mg of Mexiletine hydrochloride, USP. 100 mg of Mexiletine hydrochloride is equivalent to 83.31 mg of Mexiletine base. In addition each capsule contains the following excipients: pregelatinized starch, colloidal silicon dioxide, magnesium stearate.
How effective is mexiletine hydrochloride for the treatment of tachycardia?
Mexiletine hydrochloride, at doses of 200 to 400 mg q8h, produced a significant reduction of ventricular premature beats, paired beats, and episodes of non-sustained ventricular tachycardia compared to placebo and was similar in effectiveness to the active agents. Among all patients entered into the studies,…
What is the mechanism of action of mexiletine?
In animal studies, Mexiletine has been shown to be effective in the suppression of induced ventricular arrhythmias, including those induced by glycoside toxicity and coronary artery ligation. Mexiletine, like lidocaine, inhibits the inward sodium current, thus reducing the rate of rise of the action potential, Phase 0.