Is calcineurin an antibody?
Calcineurin A Antibody (PA5-17446)
What does calcineurin do in the body?
Introduction. Calcineurin is a ubiquitous serine/threonine protein phosphatase. It plays many important physiological roles including T-cell activation, cell cycle control, muscle and heart functions, transcription regulation, learning and memory, and apoptosis.
What is calcineurin used for?
Calcineurin inhibitors are immunosuppressants used in the management of autoimmune conditions such as lupus nephritis, idiopathic inflammatory myositis, interstitial lung disease, atopic dermatitis, and many more. In addition, they are used as mainstays for immunosuppression in solid organ transplants.
What does calcineurin inhibitor do?
Calcineurin inhibitors are immunosuppressants used to manage autoimmune conditions including but not limited to lupus nephritis, idiopathic inflammatory myositis, interstitial lung disease, atopic dermatitis, and many more. In addition, they are used as mainstays for immunosuppression in solid organ transplants.
Where is calcineurin located?
It is a ubiquitous enzyme, but is highly expressed in forebrain neurons, including striatal MSNs where it is very highly enriched (Goto et al., 1987). Calcineurin is comprised of two subunits, calcineurin A and B (Fig. 29.1D).
What calcineurin means?
Abstract. Calcineurin is a eukaryotic Ca(2+)- and calmodulin-dependent serine/threonine protein phosphatase. It is a heterodimeric protein consisting of a catalytic subunit calcineurin A, which contains an active site dinuclear metal center, and a tightly associated, myristoylated, Ca(2+)-binding subunit, calcineurin B …
What is the function of calcineurin?
Calcineurin plays a key role in regulating the transcription factor NF-AT during T-cell activation, and in mediating responses of microorganisms to cation stress.