Can rheumatoid arthritis cause mental issues?

RA patients are more prone to have anxiety, depression and cognitive impairment compared to the general healthy population. Those mental health conditions contribute to less responsiveness to treatment and higher disease activity in RA mainly due to fatigue and bodily pain.

Can rheumatoid arthritis cause neurological symptoms?

A wide spectrum of neurological conditions occur in RA, including peripheral neuropathy, encephalopathy, myelopathy, vasculitis causing neuropathy and stroke, myositis and denervation atrophy. RA patients have more neurological symptoms and deficits, based on standardized scoring criteria, than do normal controls.

Does negative RF rule out rheumatoid arthritis?

When the results show negative for both anti-CCP and RF, but the person still exhibits multiple signs and symptoms of rheumatoid arthritis, this is a good indication of seronegative rheumatoid arthritis. “Seronegative” simply means the person does not have the same antibodies that a person who is “seropositive” has.

Can rheumatoid arthritis cause schizophrenia?

Disease-specific familial risks were similar to what has been shown in previous studies. A family history of RA was associated with a tripled risk for RA (HR = 3.4, 95% CI = 3.2–3.6), and a family history of schizophrenia was associated with an 8-fold risk of schizophrenia (HR = 8.2, 95% CI = 7.6–8.8).

Can rheumatoid arthritis cause bipolar disorder?

This study revealed that patients with RA were at a higher risk of subsequent bipolar disorder. We hypothesized that this risk is linked to the mechanisms of immune dysfunction.

What are the symptoms of seronegative rheumatoid arthritis?


  • tenderness, swelling, and redness in the joints.
  • stiffness, especially in the hands, knees, ankles, hips, and elbows.
  • stiffness in the morning that lasts for longer than 30 minutes.
  • persistent inflammation.
  • symptoms that affect joints on both sides of the body.
  • fatigue.

Can you test negative for rheumatoid arthritis and still have it?

If you’re seronegative for rheumatoid arthritis (RA), you may or may not have RA. It can make it harder to get an RA diagnosis. Being seronegative for RA means that a blood test doesn’t find certain antibodies your body typically makes when you have the condition.

How does rheumatoid arthritis affect the brain?

People with RA are more likely to have narrowed or blocked arteries in the brain – the result of systemic inflammation. This can cause problems with memory, thinking and reasoning.

Can Rheumatoid arthritis cause psychosis?

For our main analysis, we combined data from all non-neurological autoimmune disorders, except for rheumatoid arthritis (given the well-established negative association reported with psychosis) and found that, overall, people with any autoimmune disorder were 40% more likely to have a psychotic disorder, such as …