What is the chemical formula of lansoprazole?

What is the chemical formula of lansoprazole?

Lansoprazole sodium

What ingredients are in lansoprazole?

Each delayed-release capsule contains enteric-coated granules consisting of 15 or 30 mg of lansoprazole (active ingredient) and the following inactive ingredients: sugar sphere, sucrose, methacrylic acid copolymer, low substituted hydroxypropyl cellulose, starch, magnesium carbonate, talc, polyethylene glycol, titanium …

What class of drug is lansoprazole?

Lansoprazole is in a class of medications called proton pump inhibitors. It works by decreasing the amount of acid made in the stomach.

What is the mechanism of lansoprazole?

Its mechanism of action is to selectively inhibit the membrane enzyme H+/K+ ATPase in gastric parietal cells. In clinical trials, lansoprazole is more effective than placebo or histamine (H2)-receptor antagonists in the treatment of reflux oesophagitis.

How is lansoprazole metabolised?

It is extensively metabolized in the liver and excreted primarily in feces via the bile, with only about to 30% a dose being excreted in urine [2,3]. The plasma elimination half-life of the drug is around 1.4 to 2 hours, but the duration of action is much longer. Lansoprazole is about 97% bound to plasma protein.

Who manufactures lansoprazole?

ALLEGAN, Mich., May 18, 2012 /PRNewswire/ — Perrigo Company (Nasdaq: PRGO;TASE) today announced that it has received final approval from the U.S. Food and Drug Administration for its abbreviated new drug application (ANDA) for Lansoprazole capsules (15 mg).

Does lansoprazole contain magnesium or aluminum?

Each delayed-release orally disintegrating tablet contains enteric-coated microgranules consisting of 15 mg or 30 mg of lansoprazole (active ingredient) and the following inactive ingredients: lactose monohydrate, microcrystalline cellulose, magnesium carbonate, hydroxypropyl cellulose, hypromellose, titanium dioxide.

Does lansoprazole contain sodium?

This medicine contains less than 1 mmol sodium (23 mg) per capsule, that is to say essentially ‘sodium-free’. Lansoprazole may interfere with the absorption of other medicinal products where gastric pH is an important determinant of oral bioavailability.

Is lansoprazole available in liquid form?

Lansoprazole (Prevacid) is a medicine that is used to decrease the amount of acid that is made by the stomach. It may be used to treat ulcers, gastroesophageal reflux (GER or GERD) and heartburn. It is available as capsule, and as an oral disintegrating tablet. Your pharmacy may also be able to make a liquid for you.

Does lansoprazole affect sodium levels?

Both the above articles support the conclusion that Lansoprazole has the lowest risk of PPI associated hyponatremia. When looking in the BNF, hyponatremia is listed as a ‘very rare’ side effect of Lansoprazole. For other PPIs, hyponatremia is listed as a ‘rare’ side effect in comparison.

How many mg is lansoprazole?

Adults—30 milligrams (mg) once a day before a meal. Your doctor may adjust your dose as needed. Children 12 years of age and older—30 mg once a day before a meal. Your doctor may adjust your dose as needed.

What is the generic brand for lansoprazole?

Lansoprazole (Prevacid) is a proton pump inhibitor (PPI) used to reduce the amount of acid in your stomach. Lansoprazole (Prevacid) may be used for healing and symptom relief of duodenal ulcers and stomach ulcers, to treat an infection caused by H.

How are lansoprazole enteric coated tablets formulated?

Formulation Development: Lansoprazole enteric coated tablets were arranged by wet granulation process and enteric coated with diverse sorts of polymers as revealed in table 1. The compression practice was executed by expending sixteen station rotary compression machines.

What are the Preformulation studies for lansoprazol?

Preformulation Studies: In preformulation studies, characterization of API (identification test by FTIR,) was executed and it was institute that all are within the range detailed in the pharmacopoeia. Characterization of Active pharmaceutical ingredient were performed Calibration Curve of Lansoprazol Table 3: Calibration curve of Lansoprazole

What is lansoprazole used to treat?

Lansoprazole is one of the classes of proton pump inhibitors, which reduce gastric acidity, an important factor in healing acid-related disorders such as gastric ulcer, duodenal ulcer and reflux oesophagitis.

What is the peak temperature of lansoprazole?

The pure lansopraz ole peak 177.84 ° C a nd formulation F9 peak at 178.91 ° C. The se minor changes may not ne cessarily indic ate potential inc ompatibility.