When should reteplase be given?

Usual Adult Dose for Myocardial Infarction 10 units administered over 2 minutes as an IV bolus as soon as possible after the onset of acute myocardial infarction (AMI) symptoms, followed 30 minutes later by a second 10 unit IV bolus injection also administered over 2 minutes.

How is retavase administered?

As soon as possible after the onset of STEMI, administer 10 units intravenously over 2 minutes. Administer a second dose of 10 units 30 minutes after the first dose. Reconstitute RETAVASE immediately before administration. Reconstitute RETAVASE only with the supplied Sterile Water for Injection.

What is the difference between alteplase and reteplase?

Reteplase is a second-generation nonglycosylated deletion mutant of alteplase. Reteplase is less fibrin specific than alteplase but has a longer half-life (18 minutes) that enables administration by double-bolus IV injection.

How is reteplase administered?

It is a third-generation recombinant form of t-PA that operates in the presence of fibrin (i.e. it is fibrin specific). Reteplase can be administered as a bolus dose (nonweight-based) rather than an infusion, which promotes rapid and safe administration.

Can reteplase be used for stroke?

Both as FDA-approved methods, recombinant tissue plasminogen activator (rt-PA, Alteplase) has been used to treat acute ischemic stroke (AIS) while recombinant plasminogen activator (rPA, Reteplase) has been especially used to treat acute myocardial infarction (AMI) in adults [11,12].

Why is streptokinase only given once?

As streptokinase is a bacterial product, the body has the ability to build up an immunity to it. Therefore, it is recommended that this medication should not be used again after four days from the first administration, as it may not be as effective and can also cause an allergic reaction.

Is rtPA and tPA the same?

tPA can be manufactured using recombinant biotechnology techniques; tPA produced by such means are referred to as recombinant tissue plasminogen activator (rtPA). Specific rtPAs include alteplase, reteplase, and tenecteplase. They are used in clinical medicine to treat embolic or thrombotic stroke.

What is retavase used for?

Retavase (reteplase) is a thrombolytic drug used to dissolve blood clots used to improve heart function and prevent congestive heart failure or death in people who have had a heart attack.

What is the difference between tPA and TNKase?

Both Retavase and TNKase are indicated only for managing acute myocardial infarction, and are not FDA-approved for acute ischemic stroke or pulmonary embolism. “tPA” is the abbreviation commonly used for the drug class that encompasses all tissue plasminogen activators.

What are the absolute contraindications of streptokinase?

Because thrombolytic therapy increases the risk of bleeding, Streptase, Streptokinase, is contraindicated in the following situations:

  • active internal bleeding.
  • recent (within 2 months) cerebrovascular accident, intracranial or intraspinal surgery (see WARNINGS)
  • intracranial neoplasm.
  • severe uncontrolled hypertension.

What should I avoid while taking Retavase?

Retavase can cause significant and sometimes fatal bleeding. Avoid intramuscular injections and other trauma to a patient administered Retavase. Minimize venipunctures. Avoid puncturing noncompressible veins, such as the internal jugular and subclavian.

What should I know about Retavase before taking it?

If possible before you receive Retavase, tell your doctor if you have a brain tumor or aneurysm, high blood pressure, hemophilia or other bleeding disorder, a history of stroke, or if you have recently had a head injury or surgery on your brain or spinal cord. You should not be treated with Retavase if you are allergic to it, or if you have:

Can Retavase and aspirin be taken together?

Heparin and aspirin have been administered concomitantly with and following the administration of Retavase® in the management of acute myocardial infarction. Because heparin, aspirin, or Retavase® may cause bleeding complications, careful monitoring for bleeding is advised, especially at arterial puncture sites.

How many units of Retavase do you give?

DOSAGE AND ADMINISTRATION. Retavase® is administered as a 10 + 10 unit double-bolus injection. Two 10 unit bolus injections are required for a complete treatment. Each bolus is administered as an intravenous injection over 2 minutes. The second bolus is given 30 minutes after initiation of the first bolus injection.