What medicines contain Alginates?

Alginate-based formulations either contain alginate as the principle active agent or combine the alginate with antacid (a type of medicine that is alkaline in nature and works by neutralising excess acid)….The products were:

  • Gaviscon Double Action.
  • Gaviscon Original.
  • Peptac.
  • Algycon.
  • Maalox RefluRAPID.
  • Rennie Duo.

What is an alginate in medicine?

Alginates are medications that work through an alternative mechanism by displacing the postprandial gastric acid pocket. This study performed a systematic review and meta-analysis to examine the benefit of alginate-containing compounds in the treatment of patients with symptoms of GERD.

Where are Alginates found?

Alginate is found in seaweeds as salts of different metals, primarily sodium and calcium, in the intercellular regions and cell walls. Its biological functions in seaweeds are of structural and ion exchange type.

What is the function of Alginates?

The conventional role of alginate in pharmaceutics includes serving as thickening, gel forming, and stabilizing agents, as alginate can play a significant role in controlled-release drug products.

Are alginates antacids?

Alginates. Alginates taken in combination with an antacid increases the viscosity of stomach contents and can protect the oesophageal mucosa from acid reflux. Some alginate-containing preparations form a viscous gel (‘raft’) that floats on the surface of the stomach contents, thereby reducing symptoms of reflux.

Is alginate good for acid reflux?

The overall results from these studies provide evidence that add-on alginate helps reduce reflux symptoms in patients with an insufficient response to PPIs. This effect is particularly high in patients with weak acid/non-acid reflux.

Is alginate safe for GERD?

In conclusion, alginate is superior to placebos and antacids for the treatment of mild GERD, and alginate monotherapy seems to be beneficial as an initial treatment for mild GERD. There are limited data comparing alginate and PPIs for the treatment of mild GERD.

Is alginate a protein?

Alginate is a bioadhesive polymer which can be advantageous for the site specific delivery to mucosal tissues. All of these properties, in addition to the nonimmunogenicity of alginate, have led to an increased use of this polymer as a protein delivery system.

What are the two types of alginate?

There are two types of alginate, fast set and regular set.

What are the advantages of alginate?

Although the alginate has several advantages such as biocompatibility, stability, adjustable porosity, and easy encapsulation of the cells, it has no specific ligand for the ASGPR of the hepatocytes.

Is alginate good for reflux?

Compared with antacids, alginate-based formulations are more effective in controlling postprandial esophageal acid exposure and in relieving reflux symptoms, including heartburn, regurgitation, vomiting and belching, with a longer duration (36–38).

What is alginate preparation?

Primarily, alginate nanoparticles are being prepared by two methods. In the “complexation method”, complex formation on the interface of an oil droplet is used to form alginate nanocapsules, and complex formation in an aqueous solution is used to form alginate nano-aggregates.

What is alginate used for?

Alginate is a naturally occurring anionic polymer typically obtained from brown seaweed, and has been extensively investigated and used for many biomedical applications, due to its biocompatibility, low toxicity, relatively low cost, and mild gelation by addition of divalent cations such as Ca 2+ [ 4 ].

What is an alginate-based formulation?

Alginate-based formulations either contain alginate as the principle active agent or combine the alginate with antacid (a type of medicine that is alkaline in nature and works by neutralising excess acid). How do they work?

Are alginates effective in the treatment of gastroesophageal reflux disease?

The management of gastroesophageal reflux (GERD) disease is based on proton-pump inhibitor (PPI) therapy. However, alginates are an alternative therapeutic approach, either as a monotherapy or in combination with PPIs that play an important role in treatment. In this article, we evaluated the following topics in relation to alginates:

Why are alginate dressings so popular in hospitals?

This all lead to the widespread use of alginate dressings all over UK and USA hospitals. They are popularly used because they contain calcium and sodium fibers from seaweeds.