What is the role of the transcription factor NF KB?

Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that is involved in inflammatory and immune responses, as well as in regulation of expression of many other genes related to cell survival, proliferation, and differentiation.

Does NF KB promote apoptosis?

In a number of contexts, and particularly in response to cellular stress, stimulation of the NF-kappaB (NF-κB) pathway promotes apoptosis. One mechanism underlying this pro-apoptotic activity is nucleolar sequestration of RelA, which is reported to cause cell death by repressing NF-κB-driven transcription.

How does PKC’s signaling role change in response to growth factor signaling versus an immune response?

PKC interacts directly with signaling molecules in growth factor cascades, but interacts with signaling inhibitors during immune signaling. PKC amplifies growth factor cascades, but turns off immune cascades.

How is NF KB activated?

Activation process (canonical/classical) Activation of the NF-κB is initiated by the signal-induced degradation of IκB proteins. This occurs primarily via activation of a kinase called the IκB kinase (IKK).

What phosphorylates NF KB?

The studies of p50 S328 phosphorylation provide the strongest evidence to date that NF-κB phosphorylation can selectively regulate NF-κB transcriptional activity by modulating DNA binding in a sequence specific manner.

How does PKC’s signaling role change in response to growth factor signaling versus an immune response quizlet?

The enzyme is inactivated. How does PKC’s signaling role change in response to growth factor signaling versus an immune response? PKC interacts directly with signaling molecules in growth factor cascades, but interacts with signaling inhibitors during immune signaling.

How does the extracellular matrix control the growth of cells quizlet?

How does the extracellular matrix control the growth of cells? Receptors on the cell surface must be in contact with the extracellular matrix in order to receive positive signals that allow the cell to live. If the receptors are not activated by binding, the cell will undergo apoptosis.

How is NF-kB regulated?

The primary mechanism for regulating NF-κB is through inhibitory IκB proteins (IκB, inhibitor of NF-κB), and the kinase that phosphorylates IκBs, namely, the IκB kinase (IKK) complex.

How does NF ΚB induce gene expression quizlet?

How does NF-κB induce gene expression? B. Phosphorylation of the inhibitor Iκ-B dissociates the complex between it and NF-κB, and allows NF-κB to enter the nucleus and stimulate transcription.