What is the purpose of GM-CSF?
A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent. Also called granulocyte-macrophage colony-stimulating factor and sargramostim.
What is a cytokine GM-CSF?
Function. GM-CSF is a monomeric glycoprotein that functions as a cytokine—it is a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes.
How is GM-CSF administered?
The GM-CSF was administered subcutaneously in 28-day cycles, such that a dose of 125 microg/m2 was delivered daily for 14 days followed by 14 days rest. Treatment cycles continued for 3 years or until disease recurrence, which could not be surgically excised.
Is GM-CSF pro or anti inflammatory?
GM-CSF was first characterized as a pro-inflammatory cytokine due to its ability to stimulate plasminogen-dependent fibrinolysis activity in mouse macrophages (Hamilton and others 1980).
What does GM-CSF do to dendritic cells?
GM-CSF (Csf-2) is a critical cytokine for the in vitro generation of dendritic cells (DCs) and is thought to control the development of inflammatory DCs and resident CD103+ DCs in some tissues.
What stimulates GM-CSF?
GM-CSF is produced by various cell types including macrophages, mast cells, T cells, fibroblasts and endothelial cells 8, 9, mostly in response to immune activation and cytokines that mediate inflammation.
Is GM-CSF a growth factor?
Granulocyte-macrophage colony-stimulating factor (GM-CSF) was first described as a growth factor that induces the differentiation and proliferation of myeloid progenitors in the bone marrow.
Is GM-CSF pro inflammatory cytokine?
Granulocyte macrophage colony stimulating factor (GM-CSF) is generally recognized as an inflammatory cytokine. Its inflammatory activity is primarily due its role as a growth and differentiation factor for granulocyte and macrophage populations.
What cells release GM-CSF?
GM-CSF is produced by multiple cell types such as activated T cells, B cells, macrophages, monocytes, mast cells, vascular endothelial cells, and fibroblasts (2).
Can GM-CSF be used as a standard therapy for sepsis?
The applicability of GM-CSF as a standard therapy for generalized sepsis is still largely understudied; however, small-scale studies available have demonstrated some improved recovery from infection, decreased hospital length of stay, decreased days requiring mechanical ventilation, and decreased medical costs. Publication types
Can csf2-deficient human glioma cells be transplanted to the human brain?
CSF2-deficient human glioma cells encapsulated in cell-impermeable hollow fibres and transplanted to mouse brains, failed to attract microglia, but stimulated astrocyte recruitment. CSF2-depleted gliomas were smaller, attracted less microglia and macrophages, and provided survival benefit in tumour-bearing mice.
What is csf2/granulocyte macrophage colony stimulating factor?
Tumour-derived CSF2/granulocyte macrophage colony stimulating factor controls myeloid cell accumulation and progression of gliomas NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys My NCBISign in to NCBISign Out PMC US National Library of Medicine
How does tumour-derived CSF2 affect the brain microenvironment?
Tumour-derived CSF2 controls recruitment of microglia and macrophages and contributes to tumour progression To study the impact of tumour-derived CSF2 on the brain microenvironment, we encapsulated human U87 and LN18 glioma cells into hollow fibres (HF) and transplanted them into the brains of immunocompetent mice.