What is human interferon alpha?
Human interferon alpha (hIFNα) is a wide biological activity cytokine that is used in hepatitis and cancer treatments. It regulates many genes that are involved in antiviral and antiproliferative activities.
What type of cells produce interferon alpha?
IFN-α The IFN-α proteins are produced mainly by plasmacytoid dendritic cells (pDCs). They are mainly involved in innate immunity against viral infection.
What is natural interferon?
Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those invaders. Interferons got their name because they “interfere” with viruses and keep them from multiplying.
How is interferon alpha produced?
Alpha interferon is produced by white blood cells other than lymphocytes, beta interferon by fibroblasts, and gamma interferon by natural killer cells and cytotoxic T lymphocytes (killer T cells). All interferons inhibit viral replication by interfering with the transcription of viral nucleic acid.
Do humans produce interferon?
interferon, any of several related proteins that are produced by the body’s cells as a defensive response to viruses. They are important modulators of the immune response.
What is the difference between interferon alpha and beta?
There are three types of interferons (IFN), alpha, beta and gamma. IFN-alpha is produced in the leukocytes infected with virus, while IFN-beta is from fibroblasts infected with virus. IFN-gamma is induced by the stimulation of sensitized lymphocytes with antigen or non-sensitized lymphocytes with mitogens.
What cells can produce interferon?
Type I interferon (IFN-alpha and IFN-beta) is secreted by virus-infected cells while type II, immune or gamma interferon (IFN-gamma) is mainly secreted by T cells, natural killer (NK) cells and macrophages.
How is interferon produced in the body?
Interferon is secreted by cells in response to stimulation by a virus or other foreign substance, but it does not directly inhibit the virus’s multiplication. Rather, it stimulates the infected cells and those nearby to produce proteins that prevent the virus from replicating within them.
What triggers interferon production?
How does human interferon alpha (Hifn-α) work?
In the case of cancer, the antiproliferative activity of human interferon alpha (hIFN-α) is achieved by direct and indirect actions. Direct action occurs via cancer cell growth inhibition by cell cycle arrest, apoptosis, or differentiation.
What is the history of interferon alfa-2a recombinant?
The first human interferon-αs, human interferon alfa-2a, recombinant (Roferon A, Hoffmann-La Roche, Inc.) and human interferon alfa-2b, recombinant (Intron A, Schering Corp.), were licensed in the United States in 1986 for the treatment of hairy cell leukemia.
How many amino acids are in interferon alfa?
Two types of human interferon, interferon alfa-2a and interferon alfa-2b, have been produced by recombinant DNA techniques and marketed for cancer chemotherapy. Each agent is a protein chain of 165 amino acids, differing from each other only at a single amino acid residue.
What is the molecular weight of pegylated interferon alfa-2b?
Pegylated interferon alfa-2b is a covalent conjugate of human interferon alfa-2b with monomethoxy-polyethylene glycol (PEG). The molecular weight of the PEG is approximately 12,000. The average molecular weight of the PEG-INTRON is approximately 31,000. The specific antiviral activity of the product is approximately 0.7 × 10 8 IU/mg protein.