Is sebaceous adenoma malignant?

A sebaceous adenoma is a small bump on a gland in your skin (sebaceous gland). It’s a harmless, benign tumor in a hair follicle.

What does Muir-Torre look like?

Muir-Torre syndrome (MTS) is a rare inherited disorder that involves at least one sebaceous tumor and/or keratoacanthoma in addition to one visceral malignancy. Sebaceous adenomas are the most common cutaneous tumors in MTS. They appear as multiple yellow papules or bumps on areas such as the trunk, face, and scalp.

What does a sebaceous adenoma look like?

Sebaceous adenoma usually presents as a small yellowish nodule on the face of middle-aged patients. It is characterized histologically by a well-circumscribed proliferation of enlarged, mature sebaceous lobules surrounded by a fibrous pseudocapsule.

Should sebaceous adenomas be removed?

Surgical Care The usual treatment of sebaceous adenoma is complete excision. Surgical treatment of sebaceous adenomas is aimed at completely removing the tumor and preventing regrowth of the tumorous tissue.

What causes sebaceous adenoma?

The cause for sporadic disease is unknown. Cases associated with Muir-Torre syndrome are due to a defect in DNA mismatch repair proteins. The best studied genes are MSH-2 on chromosome 2, which is most common, and MLH-1 on chromosome 3. Other implicated genes include MSH-6 and MLH-3.

What is the difference between Muir-Torre and Lynch syndrome?

Lynch syndrome is the predisposition to visceral malignancies that are associated with deleterious germline mutations in DNA mismatch repair genes, including MLH1 , MSH2 , MSH6 , and PMS2 . Muir-Torre syndrome is a variant of Lynch syndrome that includes a predisposition to certain skin tumors.

How common are sebaceous adenomas?

Sebaceous adenoma is a rare, benign tumor of sebaceous glands. Approximately 70% of lesions develop on the head and face, with the nose and cheek most commonly affected; 30% of lesions occur on the neck, trunk and extremities.

What are sebaceous adenomas of the eye?

Sebaceous adenomas have been described on the caruncle of the eye, eyelid, bulbar conjunctiva and buccal mucosa 6). Identification of sebaceous adenomas is crucial because of their association with Muir-Torre syndrome.

What does sebaceous carcinoma of the eyelid look like?

Sebaceous carcinoma of the eyelid typically presents as a yellow-nodule in the upper lid. The patient may have history of colon, breast, genitourinary or other skin malignancies (Muir-Torre Syndrome).* When a nodular tumor, it can cause eyelash loss, but is not painful (compared to styes).

What is sebaceous adenoma with Muir-Torre syndrome?

Sebaceous adenoma is the most common benign sebaceous gland tumor associated with Muir-Torre syndrome. Sebaceous adenomas frequently appear on the face or scalp of middle-aged and older individuals, after age 50 years.

What is the difference between transitional and sebaceous adenoma?

The transitional cells show more eosinophilic cytoplasm. Sebaceous adenoma may be treated surgically with complete excision or cryotherapy. Surgical treatment of sebaceous adenomas is aimed at completely removing the tumor and preventing regrowth of the tumorous tissue. Solitary tumors are treated by complete surgical removal with a 100% cure rate.