Is naproxen chiral?
Naproxen, a chiral compound, is often used as a nonsteroidal anti-inflammatory analgesic drug. Figure 1 displays the chiral α-carbon atom of R-naproxen and S-naproxen. As only the (+)-isomer possesses the desirable properties and therapy, it is important that the naproxen enantiomers have to be distinguished.
What is the structure of naproxen?
1: Structure of Naproxen IUPAC Name:-[d-2-(6-metoxy-2naphthyl) propionic acid]. 8 ( Fig No. 1) Molecular Formula:-C14H14O3 Molecular weight:-230.25 Melting Range:-154 0 C-159 0 C Description: 9 An anti-inflammatory agent with analgesic and antipyretic properties.
Why should naproxen be resolved?
This process allows naproxen to be synthesized by a simpler, cheaper route as a racemate instead of a single enantiomer. Not only can the two enantiomers be resolved by this process, but the “undesired” enantiomer is converted to the desired, rather than being discarded–effectively doubling the yield of product.
What is the molecular formula of naproxen sodium?
C14H13NaO3
Naproxen sodium | C14H13NaO3 – PubChem.
What kind of inhibitor is naproxen?
Naproxen is a nonselective inhibitor of COX-1 and COX-2.
What is the molecular mass of naproxen sodium?
230.26 g/molNaproxen / Molar mass
How long does it take naproxen to peak?
Peak plasma levels are reached in 2 to 4 hours. Plasma concentrations of naproxen increase proportionally with dose up to about 500mg daily; at higher doses there is an increase in clearance caused by saturation of plasma proteins.
What is the resolution factor of racemic naproxen?
Under optimal conditions, the racemic naproxen was efficiently separated with a resolution factor (R (S)) of 1.70 and a separation factor (alpha) of 1.25. This method was successfully used for the enantiomeric separation and purity assessment of naproxen in commercial naproxen sustained release tablets.
What is the melting point of naproxen?
Naproxen has a melting point of 153 degree centigrade. Naproxen is a methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6.
What is the mobility of naproxen?
Naproxen contains chromophores that absorb at wavelengths >290 nm and therefore may be susceptible to direct photolysis by sunlight. If released to soil, naproxen is expected to have moderate mobility based upon an estimated Koc of 330.
What is the volume of distribution of naproxen?
The volume of distribution of naproxen is 0.16 L/kg. In one study, the apparent volume of distribution of naproxen averaged about 8.3 L in healthy adults and about 11.9 L in patients with severe renal failure (serum creatinine 5.4-12.5 mg/dL).