What is the clinical approach to the diagnosis of neutropenia?
This review provides a succinct clinical approach to the diagnosis and treatment of neutropenia with specific recommendations on the treatment of severe chronic neutropenia with the myeloid growth factor, granulocyte colony-stimulating factor (G-CSF). Recent Findings
What are the types of neutropenia?
Hereditary neutropenia includes cyclic neutropenia (CN), severe congenital neutropenia (SCN), 2 and benign ethnic neutropenia (seen in people of African, Middle Eastern, and West Indian origin). 3 Neutropenia is caused by any condition that affects the production or survival of healthy neutrophils.
What kind of funding is there for severe chronic neutropenia?
This work was supported by a National Institutes of Health, NIAID grant for the Severe Chronic Neutropenia International Registry, grant # 5R 24AI049393-11, the Amgen Foundation and the Ella Jewell Foundation.
What is neutropenic sepsis and how is it treated?
Neutropenic sepsis (NS) is a common and predictable complication of bone marrow disorders and cytotoxic chemotherapy, with an estimated incidence of 70–100% during the neutropenic phase after intensive chemotherapy.1Patients with neutropenia are vulnerable to invasive infection, which can be rapidly overwhelming, causing septic shock and death.
How can neutropenia be prevented?
Preventing infections if you have or are liable to develop neutropenia is key. These suggestions should help: Wash your hands frequently with soap and water. Wash your hands before and after you eat, after you use the toilet, after touching pets or things outside of your house, and after you cough or sneeze.
When are growth factors indicated in the treatment of febrile neutropenia?
However, if the risk of febrile neutropenia is ≥ 30% (as assessed by neutrophil count < 500 mcL [< 0.5 × 10 9 /L], presence of infection during a previous cycle of chemotherapy, associated comorbid disease, or age > 75), growth factors are indicated.
What are the risk factors for neutropenia?
Alcohol may contribute to neutropenia by inhibiting the neutrophilic response of the marrow during some infections (eg, pneumococcal pneumonia). Immune defects can cause neutropenia.