What does TTF-1 mean in lung cancer?
Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas.
What is TTF-1 and Napsin A?
TTF-1 and Napsin A double stain: a useful marker for diagnosing lung adenocarcinoma on fine-needle aspiration cell blocks. Cancer Cytopathol.
What does Napsin a positive mean?
Background. Napsin A and thyroid transcription factor-1 (TTF-1) are known to be useful immunohistochemical markers to distinguish primary lung cancers from metastatic lung tumors. These markers are usually positive in primary lung adenocarcinomas but not metastatic adenocarcinomas in other organs.
Does TTF-1 positive mean cancer?
TTF-1 plays a key role in morphogenesis of the lungs[1] and is expressed in up to 90% of pulmonary small cell carcinoma[2]. This explains why this marker is frequently used to search for the primary origin of metastatic neuroendocrine tumours.
What does TTF positive mean?
A positive TTF1 staining has been inversely related to the proliferative activity evaluated through Ki-67 expression, usually considered as a marker of poor prognosis in NSCLC (Pelosi et al, 2001; Myong, 2003).
What does TTF-1 negative mean?
Background: Patients with thyroid transcription factor 1 (TTF1) negative lung adenocarcinoma (ADC) have been reported to have a worse prognosis and to lack epidermal growth factor receptor (EGFR) mutations. This study describes a series of sample tumors from patients with clinically confirmed lung cancer.
What does TTF 1 negative mean?
Is Napsin a positive in normal lung?
The studies showed a wide range of Napsin A positivity for each tumor entity, for example, published Napsin A positivity rates ranged from 0% to 100% in adenocarcinoma of the lung [11, 13, 16, 18, 20, 22, 24, 43–66], 0%–48% in papillary thyroid carcinoma [11, 16, 18, 19, 24], 0%–52% in clear cell renal cell carcinoma [ …
What does a positive TTF-1 mean?
What is TTF-1?
Thyroid transcription factor 1 (TTF-1) is a homeodomain-containing nuclear transcription factor which belongs to the Nkx2 gene family; it is expressed in the forebrain, thyroid and lung. TTF-1 plays a key role in morphogenesis of the lungs[1] and is expressed in up to 90% of pulmonary small cell carcinoma[2].
Do TTF-1 and achaete-scute homolog 1 (ASCL1) co-exist in SCLC?
We report that TTF-1 and achaete-scute homolog 1 (ASCL1, also known as ASH1, an E-box binding basic helix-loop-helix transcription factor, and a lineage-survival oncogene of SCLC) are coexpressed and bound to adjacent sites on target genes expressed in SCLC, and cooperatively regulate transcription.
How common is TTF-1 expression in extrapulmonary small cell carcinoma?
Agoff et al[7], Cheuk et al[15], Jones et al[16], Kaufmann et al[10], Li et al[17], Lu et al[18], McCluggage et al[19] and Yun et al[20] showed TTF-1 expression in 44%, 42%, 39%, 80%, 21%, 60%, 84% and 71% of extrapulmonary small cell cancers, respectively[7,10,15-20].
Is TTF-1 useful in the diagnosis of common bile duct cancer?
In conclusion, we report a MEEC with TTF-1 expressing small cell cancer component of the common bile duct. A literature review indicates that TTF-1 is helpful in discriminating pulmonary from extrapulmonary carcinoid tumors. In searching for the primary origin of high-grade endocrine tumours (small cell cancers), TTF-1 should, however, not be used.